The Orioles extended their winning streak to seven games after coming back to beat the Red Sox 5-4 in their series opener at Camden Yards.
Dean Kremer improved his record to 2-and-0 after striking out five batters while allowing four runs over five and two-thirds innings.
Ramon Urias went two for three with a two-run double to lead the Birds to victory.
Chris Sale was charged with the loss after allowing five runs over five innings pitched. Manager Alex Cora says the Red Sox pitcher struggled throughout his five innings of work.
Rafael Devers and Triston Casas each slugged a home run in defeat. Boston is now last in the AL East at 12-and-12. Baltimore is second in the division at 15-and-7.
Same two teams tonight in Baltimore.